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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Cancer Res. 2013 May 30;73(14):4439–4450. doi: 10.1158/0008-5472.CAN-13-0187

Table 1.

Cytotoxicity of hSGZ on breast cancer cell lines.

Cell lines Fn14
receptor		 HER2
receptor		 IC50 (nM)
 Targeting
Index*
rGel hSGZ
eB1 + ++ 835 0.1 8, 350
MDA-MB-231 +++ −− 745 0.1 7, 450
SKBr-3 ++ +++ 1, 550 0.6 2, 538
MCF7/HER2 +++ +++ 441 0.7 ] p<0.05 630
MCF7 + −− 452 2.4 188
BT-474/HR −− +++ 590 489 ] n.s ~ 1
BT-474 −− +++ 945 > 489 < 2
*

Targeting index represents IC50 of rGel/IC50 of hSGZ. Student’s t test was used to calculate p value. Data are representative of three independent experiments. n.s., not statistically significant (p>0.05).