Table 1.
Results of the Feeding Study Comparing the Effects of 50 mg/kg/day Incarnatin Treatment (50) vs Vehicle-Treated (Ctr) and Pair-Fed Groups (50P) during the 90 Day Dosing and 28 Day Recovery Phases Showing Significant Changes in Food Intake and Body Weight
| parameter | male
|
female
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dosing
|
recovery
|
dosing
|
recovery | |||||||||
| Ctr | 50 | 50P | Ctr | 50 | 50P | Ctr | 50 | 50P | Ctr | 50 | 50P | |
| body weight (g) | 541 ± 57 | 507 ± 34a | 495 ± 31a | 562 ± 44 | 543 ± 64 | 531 ± 27 | 286 ± 30 | 277 ± 25 | 275 ± 21 | 293 ± 36 | 320 ± 15a,b | 295 ± 16 |
| body weight gain (g) | 330 ± 31 | 297 ± 25a | 284 ± 29a | 12 ± 12 | 16 ± 14 | 26 ± 8 | 106 ± 28 | 96 ± 23 | 92 ± 19 | 8 ± 7 | 25 ± 13a,b | 8 ± 7 |
| food intake (g/day) | 20.0 ± 2.8 | 19.0 ± 1.7 | 27.0 ± 9.7 | 26.4 ± 3.2 | 27.3 ± 1.9 | 15.0 ± 2.4 | 13.0 ± 1.4a | 20.6 ± 2.7 | 24.1 ± 0.8a,b | 20.0 ± 0.5 | ||
| water intake (g/day) | 32.8 ± 8.2 | 35.0 ± 8.0 | 34.3 ± 7.6 | 33.3 ± 2.4 | 33.0 ± 3.1 | 34.0 ± 3.3 | 24.5 ± 9.3 | 30.3 ± 5.7 | 32.3 ± 9.8 | 37.0 ± 9.8 | 43.7 ± 4.9 | 39.3 ± 9.7 |
a
Significantly different from the control value.
b
Significantly different from the pair-fed value (p < 0.05).