TABLE D.I.

Primary and secondary outcomes in subgroups of patients, by population and intervention

Subgroup	Survival				Postoperative, intervention group
	Mean	95% ci	hr	95% ci	Mortality		Nonfatal complications		Primary tumour complications, control group		Nonsurgical procedure, control group
	(months)				(%)	(95% ci)	(%)	(95% ci)	(%)	(95% ci)	(%)	(95% ci)
	Asymptomatic or minimally symptomatic patients
Intervention	18.6	14.6 to 22.6	0.67	0.48 to 0.94a	1.6	0 to 4.8	25.6	5.9 to 45.2	na		2b
Control	12.8	7.1 to 18.6	0.78	0.72 to 0.84c	na	na	25	15.3 to 36.1	22.2	0 to 49.1
Symptomatic and asymptomatic patients
Intervention	16.0	11.1 to 20.9	0.75	0.67 to 0.84d	10	0 to 23.8	25	12.6 to 37.4	na		5.3	2 to 8.7
Control	10.0	5.1 to 14.9	0.79	0.70 to 0.90e	na		na		27	7.5 to 46.5	32.8	13.3 to 52.2
Studies using 2nd- and 3rd-generation therapy
Intervention	18.9	14.8 to 23.0	0.68	0.56 to 0.83f	3.9	0 to 11	27.4	16.4 to 38.5	na		3	0 to 5.5
Control	12.8	8.6 to 17.0	0.75	0.67 to 84g	na		na		25	17 to 33	27	12.5 to 41.6
Studies using 1st-generation therapy
Intervention	13.4	10.6 to 16.2	0.73	0.59 to 0.90h	5.3	0 to 14.1	23.7	10 to 37.4	28.2	2.5 to 53.9	6.7i
Control	8.1	1.7 to 14.8	0.81	0.72 to 0.92j	na		na		na		32i

^aTest for heterogeneity was significant (data from six studies).

^bOnly 1 of 6 studies reported on non-resection surgical procedures in the intervention group.

^cTest for heterogeneity was nonsignificant after data from the study by Galizia et al., 2008¹¹ were excluded.

^dTest for heterogeneity was significant (data from nine studies).

^eTest for heterogeneity was nonsignificant after data from the studies by Konyalian et al., 2007²⁴, Temple et al., 2004¹³, and Venderbosch et al., 2011⁷ were excluded.

^fTest for heterogeneity was significant (data from ten studies).

^gTest for heterogeneity was nonsignificant after data from the studies by Aslam et al., 2010²¹, and Galizia et al., 2008¹¹ were excluded.

^hTest for heterogeneity was significant (data from five studies).

ⁱOnly one of five studies reported non-resection surgical procedures in the intervention and control groups.

^jTest for heterogeneity was nonsignificant after data from the study by Konyalian et al., 2007²⁴ were excluded.

ci = confidence interval; hr = hazard ratio; na = not applicable.