Table 3.
Incidence of and hazard ratios for chronic kidney disease (CKD) in patients with and without (controls) psoriasis
| Variable | All psoriasis | Mild psoriasis | Severe psoriasis | |||||
|---|---|---|---|---|---|---|---|---|
| Controls (n=689 702) | Patients (n=143 883) | Controls (n=654 210) | Patients (n=136 529) | Controls (n=35 492) | Patients (n=7354) | |||
| Follow-up time (years): | ||||||||
| Mean (SD) | 5.38 (3.99) | 5.23 (3.94) | 5.33 (3.98) | 5.16 (3.93) | 6.25 (4.07) | 6.40 (4.00) | ||
| Median (IQR) | 4.52 (1.98 to 8.47) | 4.28 (1.89 to 8.22) | 4.46 (1.94 to 8.41) | 4.20 (1.86 to 8.11) | 5.79 (2.78 to 9.45) | 5.98 (2.98 to 9.48) | ||
| No of person years | 3 708 255 | 751 825 | 3 486 541 | 704 732 | 221 714 | 47 092 | ||
| No (%) of new cases of CKD | 50 206 (7) | 11 483 (8) | 47 204 (7) | 10 268 (8) | 3002 (9) | 1215 (17) | ||
| Incidence per 1000 person years (95% CI) | 13.54 (13.42 to 13.66) | 15.27 (15.00 to 15.56) | 13.54 (13.42 to 13.66) | 14.57 (14.29 to 14.85) | 13.54 (13.06 to 14.03) | 25.80 (24.39 to 27.29) | ||
| Hazard ratio (95% CI) for incident CKD: | ||||||||
| Unadjusted | 1 (ref) | 1.13 (1.11 to 1.15) | 1 (ref) | 1.08 (1.05 to 1.10) | 1 (ref) | 1.90 (1.78 to 2.04) | ||
| Adjusted* | 1 (ref) | 1.05 (1.02 to 1.07) | 1 (ref) | 0.99 (0.97 to 1.02) | 1 (ref) | 1.93 (1.79 to 2.08) | ||
| Hazard ratio (95% CI) for incident ESRD | ||||||||
| Unadjusted | 1 (ref) | 1.25 (0.96 to 1.65) | 1 (ref) | 1.08 (0.80 to 1.46) | 1 (ref) | 3.59 (1.73 to 7.46) | ||
| Adjusted* | 1 (ref) | 1.15 (0.84 to 1.58) | 1 (ref) | 0.98 (0.69 to 1.38) | 1 (ref) | 4.15 (1.70 to 10.11) | ||
SD=standard deviation; IQR=interquartile range; ESRD=end stage renal disease.
*Adjusted for sex, age, cardiovascular disease, diabetes mellitus, hyperlipidemia, hypertension, use of non-steroidal anti-inflammatory drugs, BMI (body mass index).