Table 2.

Primary and secondary outcomes during 12 month intervention period

Outcomes and period	Intervention group			Control group		No of patients in multivariable analysis	Adjusted effect estimate* (intervention v control) (95% CI)	P value	ICC
	No of patients	Mean (SD)		No of patients	Mean (SD)
Primary outcome
Adherence level to depot treatment:
Baseline	72	69% (16%)		55	67% (16%)	123	11.5% (3.9% to 19.0%)†	0.0003	0.28
One year study period	75	85% (15%)		56	71% (22%)
Secondary outcomes
Subjective quality of life (DIALOG mean score):
Baseline	51	4.4 (0.9)		34	4.9 (1.0)	57	0.71 (0.26 to 1.15)‡	0.002	<0.001
End of study period	56	5.2 (0.8)		32	4.9 (1.0)
Satisfaction with medication (one item mean score):
Baseline	51	4.9 (1.5)		34	5.0 (1.5)	57	0.26 (−0.74 to 1.27)†	0.610	0.51
End of study period	56	5.6 (1.5)		32	5.3 (1.3)
Outcomes in intervention group:
No of voluntary hospital admissions	78	0.15 (0.49)		60	0.13 (0.43)
No of involuntary hospital admissions	78	0.31 (0.96)		60	0.27 (0.63)
Adverse events
No of suicide attempts	77	0.13 (0.41)		58	0.10 (0.41)
No of violent incidents	77	0.25 (0.78)		58
No of police arrests	77	0.18 (0.53)		57
No of patients achieving at least 95% adherence:
Baseline	72	5 (7%)		55	1 (2%)	123	8.21 (2.00 to 33.67)§	0.003	0.04
One year study period	75	21 (28%)		56	3 (5%)
No of patients achieving clinical improvement on CGI:
End of study period	57	33 (58%)		44	18 (41%)	96	2.73 (0.64 to 11.59)§	0.174	0.44

CGI=clinical global improvement; ICC=model based intracluster correlation coefficient.

*Each model adjusted for baseline measure of outcome (except when clinical global improvement was outcome), mental illness needs index score category (low v high), and average treatment cycle during baseline, and includes a random effect for team.

†Adjusted difference in means (95% CI) from linear mixed effects model.

‡Adjusted difference in means from random effects model fitted by generalised least squares.

§Adjusted odds ratio (95% CI) from logistic mixed effects model.