Table 1.

Cancer spectrum of USA family R members age 20 + and syndrome risk ≥ 25%

Cancer sites	EPCAM family genetic test results
	Pos + OGCa	Negative	Not tested	Total
	Colon	22	1	27	50
Skin	2b	1	2	5
Small intestine	1c	1d	1c	3
Stomach	1c	0	1	2
Unknown primary	1	0	2	3
Breast	0	2	5c	7
Upper uroepithelial	0	0	3c	3
Lymphoma	0	0	3	3
Lung	0	0	2	2
Brain	0	0	2	2
Prostate	0	1	1	2
Pancreas	0	0	1	1
Testicle	0	0	1	1
Urinary bladder	0	0	1	1
Female organ?	0	0	1c	1
Endometrium	0	1	0	1
Leukemia	0	1	0	1
No cancer	13	29	201	243
Total individuals	36	37	250	323

EPCAM, epithelial cell adhesion molecule; OGC, obligate gene carrier.

^aIncludes those tested positive plus Obligate Gene Carriers (child tested positive).

^bBoth individuals also diagnosed with colon cancer.

^cOne individual also diagnosed with colon cancer.

^dThis individual also diagnosed with melanoma.

Of the 57 individuals tested, 20 are positive and 37 are negative.