Table 1. Assessment of cytotoxicity and anti-HSV-2 activity of HM.
Virus | HM (µg/ml) |
Acyclovir (µg/ml) |
||||
---|---|---|---|---|---|---|
CC50 a | EC50 b | SIc | CC50 a | EC50 b | SIc | |
HSV-2G (ATCC 734) | 30 | 1.5 ± 0.1 | 20.0 | 130 | 2.9 ± 0.1 | 44.8 |
Clinical Isolate 1 | 1.7 | 17.6 | 3.5 | 37.1 | ||
Clinical Isolate 2 | 1.5 | 20.0 | 3.1 | 41.9 | ||
Clinical Isolate 3 | 1.1 | 27.3 | 5.2 | 25.0 | ||
Clinical Isolate 4 | 1.6 | 18.7 | 4.4 | 29.5 | ||
TK deficient strain | 2.8 | 10.7 | >30 | - |
The 50% cytotoxic concentration (CC50) for Vero cells.
Concentration(s) of HM producing 50% inhibition (EC50) of virus-induced cytopathic effect of three separate experiments.
Selectivity index (SI) = CC50/EC50