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. 2013 Oct 22;8(10):e77937. doi: 10.1371/journal.pone.0077937

Table 1. Assessment of cytotoxicity and anti-HSV-2 activity of HM.

Virus HM (µg/ml)
Acyclovir (µg/ml)
CC50 a EC50 b SIc CC50 a EC50 b SIc
HSV-2G (ATCC 734) 30 1.5 ± 0.1 20.0 130 2.9 ± 0.1 44.8
Clinical Isolate 1 1.7 17.6 3.5 37.1
Clinical Isolate 2 1.5 20.0 3.1 41.9
Clinical Isolate 3 1.1 27.3 5.2 25.0
Clinical Isolate 4 1.6 18.7 4.4 29.5
TK deficient strain 2.8 10.7 >30 -
a

The 50% cytotoxic concentration (CC50) for Vero cells.

b

Concentration(s) of HM producing 50% inhibition (EC50) of virus-induced cytopathic effect of three separate experiments.

c

Selectivity index (SI) = CC50/EC50