Table 3. Efficacy of HM ointment in HSV-2 genital infection model.
Drug Treatment | No. of animals | No. of animals survived | No. of death | Survival (%) | Days-to-mortality (mean±S.D. days)a | No. of vaginal samples containing HSV-2 |
|
---|---|---|---|---|---|---|---|
Before treatment | After treatment/death | ||||||
HM 0.5% | 20 | 14 | 06 | 70*b | 11.15 ± 2.34* | 20 | 07* |
HM 0.25% | 20 | 09 | 11 | 45* | 9.45 ± 2.66* | 20 | 15* |
ACV 5% | 20 | 16 | 04 | 80* | 11.85 ± 1.33* | 20 | 05* |
Vaseline Base | 20 | 02 | 18 | 10** | 7.65 ± 2.87** | 20 | 18** |
Virus control | 20 | 01 | 19 | 5 | 6.75 ± 1.93 | 20 | 19 |
Uninfected | 20 | 20 | 0 | 100 | NAc | 0 | 0 |
Average time for mortality to occur following infection.
b P value from t-test between test group and virus control group. * P > 0.01; ** P < 0.05
Not applicable.