Figure 6. In 5-HTT-/- mice subjected to the WM a low number of NeuroD positive cells is correlated with a poor performance in the Morris water maze.

Applying the Spearman`s test in the quantitative immunohistochemistry study revealed a linear dependence between the learning performance (decreasing learning performance is expressed as increasing area under the learning curve; AuC) and the number of NeuroD-immunoreactive (ir) cells could be found in the temporal hippocampus of 5-HTT-/- WM mice. A significant negative correlation between AuC and the number of NeuroD-ir (Data represent arithmetic mean per section) cells in both, the suprapyramidal blade of the subgranular zone (SGZ) as well as in both blades of the SGZ. A trend towards a negative correlation was found in the infrapyramidal blade of the SGZ.