Table 2. The effects of genistein on cell cycle distribution of LAPC-4 and LNCaP cells.
| LAPC-4 cells |
LNCaP cells |
|||||||
|---|---|---|---|---|---|---|---|---|
| Genistein dose | Sub G | G0/G1 | S | G2/M | Sub G | G0/G1 | S | G2/M |
| Control | 9.46 (3.8) | 71.98 (5.1) | 6.38 (3.3) | 12.25 (2.8) | 7.06 (1.5) | 73.85 (2.5) | 8.04 (2.1) | 11.05 (2.8) |
| 0.5 µmol/L | 13.63 (1.5) | 62.69 (9.4) | 6.12 (4.9) | 17.66 (2.6) | 7.00 (1.5) | 74.96 (5.4) | 8.02 (2.9) | 10.02 (4.6) |
| 1.0 µmol/L | 18.37 (6.2) | 59.58*(4.1) | 4.18 (0.8) | 17.78 (5.6) | 4.44* (0.9) | 82.12* (4.3) | 9.09 (2.4) | 4.42* (2.4) |
| 10 µmol/L | 25.1**(2.6) | 52.3**(2.9) | 3.30 (0.9) | 19.31*(2.8) | 7.08 (1.5) | 72.81 (4.8) | 7.80 (1.8) | 12.31 (2.6) |
| 25 µmol/L | 34.2**(4.2) | 40.8**(4.3) | 3.84 (4.1) | 21.19*(3.5) | 13.0** (2.5) | 61.78**(3.2) | 5.84 (2.1) | 19.4* (3.6) |
| 50 µmol/L | 40.4**(0.8) | 31.2**(3.0) | 2.30 (0.9) | 26.1**(2.0) | 9.37** (1.6) | 43.03**(3.4) | 3.30*(1.1) | 34.3** (3.9) |
Propidium iodide-stained cells were analyzed using a flow cytometer. Results in the table represent the mean ± SD of three experiments.
* p<0.05, ** p<0.01, compared to the vehicle control group. Numbers between brackets are for standard deviations.