Figure 4. Collagen and bone material properties in Postn -/- and Postn +/+ mice.
(A) Concentration of immature (dihydroxylysinonorleucine, DHLNL and hydroxylysinonorleucine, HLNL) and mature (pyridinoline, PYD and deoxypyridinoline, DPD) crosslinks in bone extracts. (B) Volumetric BMD (HA: hydroxyapatite) evaluated by microCT in three identical cubes distributed from the outside to the inside of cortical bone (Ec, endocortical , Ic, intra-cortical, Ps, periosteal. (C) Bone material properties evaluated by nanoindentation. * p<0.05,** p<0.01 compared to Postn +/+. Bars show mean (± sem) of n= 4 animals /gr.