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. 2013 Oct 22;8(10):e79661. doi: 10.1371/journal.pone.0079661

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© 2013 Adhi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a). Quantification of fluorescein leakage from retinal vessels into the vitreous in un-injected diabetic eyes (n=14) showing a 310% increase in leakage 25 minutes following intraperitoneal injection of sodium fluorescein when compared to un-injected non-diabetic eyes (n=8) [p<0.0001] (b-d). Quantification of fluorescein leakage from retinal vessels into the vitreous in un-injected diabetic eyes (n=8) compared to un-injected non-diabetic eyes (n=8) showing no difference in leakage at 5, 15, and 20 minutes following intraperitoneal injection of sodium fluorescein. (e). Quantification of fluorescein leakage from retinal vessels into the vitreous of diabetic eyes pre-injected with AAV2/8-sCD59 (n=16) showing a 60% reduction in leakage when compared to AAV2/8-pA injected control eyes (n=14) [p=0.003]. (f). Quantification of fluorescein leakage from retinal vessels into the vitreous of diabetic eyes pre-injected with AAV2/8-pA injected control eyes (n=14) and Ringer’s lactate (R/L) injected control eyes (n=16) showing no difference in leakage and suggesting that the injection procedure rather than the AAV is responsible for an increase in vascular leakage in injected eyes above that of the un-injected diabetic eyes. RFU, relative fluorescence units. n represents the number of eyes.