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View full-text article in PMC

. 2013 Oct 22;8(10):e79661. doi: 10.1371/journal.pone.0079661

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© 2013 Adhi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a). Representative images of retinal flat-mounts from un-injected diabetic eyes (n=7) and un-injected non-diabetic eyes (n=4), following intra-cardiac perfusion with fluorescein-dextran. Retina from un-injected diabetic mouse shows areas of capillary non-perfusion (white arrows). Scale bars = 120μm. (b). Representative images of retinal flat-mounts following intra-cardiac perfusion of fluorescein-dextran shows attenuation of areas of non-perfusion of retinal vessels in AAV2/8-sCD59 injected diabetic eyes (n=6), while AAV2/8-pA injected diabetic eyes (n=4) show areas of capillary non-perfusion (white arrows). Scale bars = 120μm. n represents the number of eyes.