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. 2013 Oct 22;8(10):e79661. doi: 10.1371/journal.pone.0079661

Figure 3. sCD59 Attenuates Retinal Ganglion Cell Apoptosis in Diabetic Mice.

Figure 3

(a). Quantification of TUNEL positive ganglion cells from 23 retinal sections from un-injected diabetic eyes (n=7) showing a 360% increase in apoptosis when compared to 13 retinal sections from un-injected non-diabetic eyes (n=6) [p=0.001]. (b). Quantification of TUNEL positive ganglion cells showing a 200% reduction in ganglion cell apoptosis in 24 retinal sections of diabetic eyes pre-injected with AAV2/8-sCD59 (n=7) compared to 20 retinal sections of diabetic eyes pre-injected with AAV2/8-pA (n=6) [p=0.0004]. n represents the number of eyes. Note: TUNEL positive cells were assessed and quantified from both central as well as peripheral retinal sections in all groups.