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View full-text article in PMC

. 2013 Oct 22;8(10):e79661. doi: 10.1371/journal.pone.0079661

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© 2013 Adhi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a). Representative retinal sections stained for GFAP from un-injected diabetic eyes (n=7) and un-injected non-diabetic eyes (n=6) showing similar staining of astrocytes (white arrowheads) in both groups. Scale bars = 29μm. Insets: Higher magnification of stained astrocytes. (b). Quantification of GFAP staining in un-injected diabetic eyes (n=7) and un-injected non-diabetic eyes (n=6) showing no difference in the staining of the astrocytes between the two groups. (c). Representative retinal sections stained for GFAP showing increased staining of astrocytes and Müller cells in AAV2/8-sCD59 injected diabetic eyes (n=7), when compared to AAV2/8-pA injected diabetic eyes (n=6). White arrowheads indicate Müller cell processes. Scale bar = 29μm. Insets: Higher magnification. (d). Quantification of GFAP staining showing a 180% increase in staining of the glial cells in AAV2/8-sCD59 injected diabetic eyes (n=7) when compared to AAV2/8-pA injected diabetic control eyes (n=6) [p=0.006]. n represents the number of eyes. Note: GFAP staining was assessed and quantified from both central as well as peripheral retinal sections in all groups.