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. 2013 Oct 22;8(10):e76994. doi: 10.1371/journal.pone.0076994

Figure 5. Identification of selected miRNAs in Urine.

Figure 5

(A) Box plots representing the urine expression level of four miRNAs (miR-205, miR-214, miR-221 and miR-99b) in urine from 36 PCa patients and 12 healthy individuals as assessed by qRT-PCR. Expression levels of the miRNAs are normalized to RNU48 as endogenous control. Statistically significant differences were determined using Student’s T-test. We detected significant decreased expression of miR-205 (p<0.05), miR-214 (p<0.05) in urine of PCa patients as compared to healthy controls. No significant difference in expression levels of miR-221 and miR-99b were observed. *denotes p<0.05. (B) Receiver operating characteristic (ROC) curve analysis of four miRNAs was used to differentiate PCa patients from healthy individuals. The area under the ROC curve (AUC) for each miRNA conveys its accuracy for differentiation of PCa patients and healthy subjects in terms of sensitivity and specificity.