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. 1972 Jul;24(1):120–126. doi: 10.1128/am.24.1.120-126.1972

Influence of Mouse Strain on the Assayed Potency (Unitage) of Tetanus Toxoid

M Carolyn Hardegree 1, Margaret Pittman 1, Clifford J Maloney 1
PMCID: PMC380557  PMID: 5057368

Abstract

The assayed potency of an adsorbed tetanus toxoid C2, relative to the international standard for tetanus toxoid (adsorbed), varied significantly with the use of different strains of mice. The unitage was highest with NIH mice, and it was not significantly different from that with CFW mice. With CDF1 and BALB/c mice, however, the assayed potency was significantly lower than with NIH mice. C3H mice failed to respond to the dose range of the toxoids employed with the other four strains. The significance of the influence of the mouse strain on the designation of a prescribed unit requirement for tetanus toxoid, adsorbed, relative to human efficacy is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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