Figure 9. Transplanted human cells produce FVIII.

The graph represents ELISA measurements of human FVIII in the plasma of untransplanted uPA-NOG mice (n = 5) and mice transplanted with human fetal liver cells (n = 22). Results are compared to a calibrated human plasma standard from the assay manufacturer and an independent human plasma sample obtained from our institute (n = 3). The calibrated plasma standard has 108% FVIII activity of a reference standard, which is equivalent to 0.95 IU/ml. Data are shown as the mean ± standard deviation.