Table 4. Comparison of the most common aberrations and their frequencies in CDC and UUT-UC tumors.
|
Recurrent gains
|
|
|
|
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|---|---|---|---|---|---|---|---|
|
CDC T1-T2 (n=7)
|
CDC T3-T4 (n=22)
|
UUT-UC Ta-T1 (n=16)
|
UUT-UC ≥T2 (n=10)
|
||||
| Region | n (%) | Region | n (%) | Region | n (%) | Region | n (%) |
| 1q | - | 1q | 1 (4.5) | 1q | 2 (12.5) | 1q | 2 (20) |
| 2q | 1 (14.2) | 2q | 2 (9.0) | 2q | 1 (6.25) | 2q | 2 (20) |
| 3q | 1 (14.2) | 3q | 3 (13.5) | 3q | 2 (12.5) | 3q | 2 (20) |
| 5p | - | 5p | 1 (4.5) | 5p | 2 (12.5) | 5p | 5 (50) |
| 6p24 | - | 6p24-ter | - | 6p24-ter | 6 (37.5) | 6p24-ter | 3 (30) |
| 7 | - | 7 | - | 7 | 4 (25.0) | 7 | 1 (10) |
| 8q | - | 8q | - | 8q | 3 (18.75) | 8q21 | 6 (60) |
| 12q | 2 (28.4) | 12q | 5 (22.5) | 12q | 1 (6.25) | 12q | 2 (20) |
| 13q22-24 | 1 (14.2) | 13q22-24 | 5 (22.5) | 13q22-24 | 2 (12.5) | 13q22-24 | 1 (10) |
| Recurrent losses | |||||||
| CDC T1-T2 (n=7) | CDC T3-T4 (n=22) | UUT-UC Ta-T1 (n=16) | UUT-UC ≥T2 (n=10) | ||||
| Region | n (%) | Region | n (%) | Region | n (%) | Region | n (%) |
| 1p36 | - | 1p36 | 7 (31.8) | 1p36 | - | 1p36 | - |
| 3p | - | 3p | 3 (13.5) | 3p | 1 (6.25) | 3p | 4 (40) |
| 6p24-25 | - | 6p24-25 | 4 (18.0) | 6p24-25 | - | 6p24-25 | - |
| 8p | 1 (14.2) | 8p | 10(45.5) | 8p | 3 (18.75) | 8p | 3 (30) |
| 9p | 2 (28.4) | 9p | 5 (22.5) | 9p | 5 (31.25) | 9p | 3 (30) |
| 9q | 1 (14.2) | 9q | 3 (13.5) | 9q | 11 (68.75) | 9q | 2 (20) |
| 10q23-ter | 2 (28.4) | 10q23-ter | 3 (13.5) | 10q23-ter | 1 (6.25) | 10q23-ter | 4 (40) |
| 13q11-31 | - | 13q11-31 | 3 (13.5) | 13q11-31 | 1 (6.25) | 13q11-31 | 5 (50) |
| 15q25-ter | 1 (14.2) | 15q25-ter | 4 (18.0) | 15q25-ter | - | 15q25-ter | - |
| 16p12 | 2 (28.4) | 16p12 | 7 (31,8) | 16p12 | 1 (6.25) | 16p12 | 2 (20) |
| 17p | 1 (14.2) | 17p | 3 (13.5) | 17p | 3 (18.75) | 17p | 4 (40) |
| 20 | 2 (28.4) | 20 | 5 (22.5) | 20 | - | 20 | - |