Table 2. Biomarker Expression in Tissue and Plasma in Relation to Breast Cancer Receptor Subtypes.
| CHARACTERISTICS |
RECEPTOR-SUBTYPE
|
P-VALUE | ||||||
|---|---|---|---|---|---|---|---|---|
| HR+/HER2- | HR+/HER2+ | HR-/HER2+ | TNBC | |||||
| N (%) | N (%) | N (%) | N (%) | |||||
| CD44 | ||||||||
| Positive (n=60) | 24 (40.0) | 9 (15.0) | 5 ( 8.3) | 22 (36.7) | 0.025* | |||
| Negative (n=66) | 36 (54.4) | 10 (15.2) | 10 (15.2) | 10 (15.2) | ||||
| CD24 | ||||||||
| Positive (n=75) | 30 (40.0) | 14 (18.7) | 12 (16.0) | 19 (25.3) | 0.213 | |||
| Negative (n=51) | 30 (58.8) | 5 ( 9.8) | 3 ( 5.9) | 13 (25.5) | ||||
| CD44+/CD24- | ||||||||
| Positive (n=37) | 10 (27.0) | 4 (10.8) | 3 ( 8.1) | 20 (54.1) | <0.001* | |||
| Negative (n=89) | 50 (56.2) | 15 (16.8) | 12 (13.5) | 12 (13.5) | ||||
| CD24+/CD44- | ||||||||
| Positive (n=50) | 18 (36.0) | 9 (18.0) | 10 (20.0) | 13 (26.0) | 0.132 | |||
| Negative (n=76) | 42 (55.3) | 10 (13.1) | 5 (6.6) | 19 (25.0) | ||||
| PTEN | ||||||||
| Positive (n=80) | 46 (57.5) | 8 (10.0) | 11 (13.8) | 15 (18.7) | 0.002* | |||
| Negative (n=62) | 17 (27.4) | 14 (22.6) | 8 (12.9) | 23 (37.1) | ||||
| pAkt | ||||||||
| Negative (n=62) | 33 (53.2) | 9 (14.5) | 7 (11.3) | 13 (21.0) | 0.056 | |||
| Positive (n=64) | 21 (32.8) | 13 (20.3) | 12 (18.8) | 18 (28.1) | ||||
| FOXO1 | ||||||||
| Positive (n=59) | 34 (57.6) | 9 (15.3) | 6 (10.2) | 10 (16.9) | 0.002* | |||
| Negative (n=80) | 28 (35.0) | 11 (13.8) | 10 (12.5) | 31 (38.7) | ||||
| | ||||||||
| CHARACTERISTICS | MEAN±SD | MEAN±SD | MEAN±SD | MEAN±SD | TOTAL | |||
|
| ||||||||
| Plasma IGF-I (ng/ml) | ||||||||
| Premenopausal | 118±71 | 112±61 | 92.5±55 | 134±68 | 137±69 | |||
| Postmenopasual | 112±52 | 117±68 | 110±48 | 122±68 | 116±65 | |||
| P-Value=0.053 | P-Value=0.902 | P-Value=0.994 | P-Value=0.318 | P-Value=0.0318* | ||||
| Plasma IGFBP3 (μg/ml) | ||||||||
| Premenopausal | 2.8±1.2 | 3.1±0.9 | 2.8±1.7 | 2.9±0.9 | 2.9±0.9 | |||
| Postmenopasual | 3.0±0.9 | 2.7±1.5 | 3.8±0.5 | 2.9±1.0 | 2.8±1.1 | |||
| P-value=0.432 | P-value=0.696 | P-value=0.223 | P-value=0.850 | P-value=0.850 | ||||
Abbreviations: HR–Hormonal Receptor (Estrogen/Progesterone Receptor), HER2 (human epidermal growth-factor-receptor 2), TNBC – Triple Receptor-Negative Breast Cancer (ER-/PR-/HER2-), SD–Standard Deviation. *P-value<0.05 is significant.