Table 3. CD44, CD24 Expression in Relation to Tumor Characteristics and Ki67, PTEN, pAkt, and FOXO1 Expression.
| VARIABLE |
CD44
|
CD24
|
CD44/CD24
|
CD24/CD44
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | |||
| N (% | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | |||
| ER status | ||||||||||
| Positive | 32(53.3) | 44(66.7) | 42(56.0) | 34(66.7) | 14(37.8) | 62(69.7) | 26(52.0) | 50(65.8) | ||
| Negative | 28(46.7) | 22(33.3) | 33(44.0) | 17(33.3) | 23(62.2) | 27(30.3) | 24(48.0) | 26(34.2) | ||
| P-Value=0.147 | P-Value=0.268 | P-Value=0.001* | P-Value=0.139 | |||||||
| PR status | ||||||||||
| Positive | 28(46.7) | 36(54.5) | 35(46.7) | 29(56.9) | 13(35.1) | 51(57.3) | 23(46.0) | 41(53.9) | ||
| Negative | 32(53.3) | 30(45.5) | 40(53.3) | 22(43.1) | 24(64.9) | 38(42.7) | 27(54.0) | 35(46.1) | ||
| P-Value=0.476 | P-Value=0.281 | P-Value=0.031* | P-Value=0.467 | |||||||
| HER2 status | ||||||||||
| Positive | 14(23.3) | 20(30.3) | 26 (34.7) | 8(15.7) | 7 (18.9) | 27(30.3) | 19(38.0) | 15(19.7) | ||
| Negative | 46(76.7) | 46(69.7) | 49 (65.3) | 43(84.3) | 30(81.1) | 62(69.7) | 31(62.0) | 61(80.3) | ||
| P-Value=0.426 | P-Value = 0.024* | P-Value=0.270 | P-Value=0.039* | |||||||
| Ki67 | ||||||||||
| Low | 30(51.7) | 48(82.8) | 43(63.2) | 35(72.9) | 16(44.4) | 62(77.5) | 31(68.9) | 47(66.2) | ||
| High | 28(48.3) | 10(17.2) | 25(36.8) | 13(27.1) | 20(55.6) | 18(22.5) | 14(31.1) | 24(33.8) | ||
| P-Value=0.001* | P-Value=0.319 | P-Value=0.001* | P-Value=0.840 | |||||||
| Tumor size | ||||||||||
| ≤ 5 cm | 41(70.7) | 41(65.1) | 44(62.9) | 38(74.5) | 26(72.2) | 56(65.9) | 28(60.9) | 54(72.0) | ||
| > 5 cm | 17(29.3) | 22(34.9) | 26(37.1) | 13(25.5) | 10(27.8) | 29(34.1) | 18(39.1) | 21(28.0) | ||
| P-Value=0.562 | P-Value=0.237 | P-Value=0.531 | P-Value=0.232 | |||||||
| Lymph Node | ||||||||||
| Negative | 28(47.5) | 27(42.9) | 29 (40.8) | 26(51.0) | 18(50.0) | 37(43.0) | 19(40.4) | 36(48.0) | ||
| Positive | 31(52.5) | 36(57.1) | 42 (59.2) | 25(49.0) | 18(50.0) | 49(57.0) | 28(59.6) | 39(52.0) | ||
| P-Value=0.716 | P-Value = 0.276 | P-Value=0.551 | P-Value=0.458 | |||||||
| PTEN | ||||||||||
| Positive | 30(52.6) | 35(58.3) | 35(48.6) | 30(66.7) | 12(35.3) | 53(63.9) | 22(44.9) | 43(63.2) | ||
| Negative | 27(47.4) | 25(41.7) | 37(51.4) | 15(33.3) | 22(64.7) | 30(36.1) | 27(55.1) | 25(36.8) | ||
| P-Value=0.580 | P-Value=0.06 | P-Value=0.007* | P-Value=0.06 | |||||||
| pAkt | ||||||||||
| Negative | 19(40.4) | 29(51.8) | 23(35.9) | 25(64.1) | 10(33.3) | 38(52.1) | 17(38.6) | 31(52.5) | ||
| Positive | 28(59.6) | 27(48.2) | 41(64.1) | 14(35.9) | 20(66.7) | 35(47.9) | 27(61.4) | 28(47.5) | ||
| P-Value=0.322 | P-Value=0.008* | P-Value=0.127 | P-Value=0.170 | |||||||
| FOXO1 | ||||||||||
| Positive | 29(50.9) | 26(43.3) | 26(36.1) | 29(64.4) | 18(51.4) | 37(45.1) | 16(32.7) | 39(57.4) | ||
| Negative | 28(49.1) | 34(56.7) | 46(63.9) | 16(35.6) | 17(48.6) | 45(54.9) | 33(67.3) | 29(42.6) | ||
| P-Value=0.461 | P-Value=0.004* | P-Value=0.551 | P-Value=0.009* | |||||||
Abbreviations: ER–Estrogen Receptor, PR– Progesterone Receptor. *P-value<0.05 is significant.