Table 6. Association of CD44+/CD24- Phenotype and Disease Outcome by Study and Multivariate Analysis.
| STUDY (REFERENCE) |
SAMPLE
|
CD44+/CD24- | REDUCED DFS† |
MULTIVARIATE ANALYSIS††
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (N) | Ethnicity | % | P-VALUE | HR††† (95% CI) | P-VALUE | |||||
| Lin, 2012 [34] | 147 | Asian | 70 | 0.001* | 2.2 (1.3-3.7) | 0.002* | ||||
| Perrone, 2012 [36] | 56 | Caucasian | 91 | <0.05 * | 6.0 (1.8-19.9) | 0.003* | ||||
| Xu, 2012 [37] | 1086 | Asian | 31 | n.s | 1.2 (0.8-1.7) | 0.32 | ||||
| Giatromanolaki, 2010 [27] | 139 | Caucasian | 29 | n.s. | 1.3 | 0.18 | ||||
| Lee, 2011 [33] | 92 | Asian | 40 | 0.043* | - | - | ||||
| Honeth, 2008 [26] | 240 | Caucasian | 31 | n/a | - | - | ||||
| Mylona, 2008 [35] | 155 | Caucasian | 59 | 0.074 | - | - | ||||
| Abraham, 2005 [24] | 136 | Caucasian | 22 | n.s. | - | - | ||||
| Kim, 2011 [38] | 643 | Asian | 21 | 0.003 * | 0.7 (0.5-0.9) | 0.02* | ||||
| Vadgama, 2013 | 126 | African-American, Hispanic | 29 | 0.05 * | 1.0 (0.5-2.1) | 0.9 | ||||
Abbreviations: DFS-Disease Free Survival, HR-Hazard Ratio, CI–Confidence Interval, n.s–Not Significant (P>0.05). n/a-information is not available, AA-African-American, Hisp-Hispanic/Latina.
* P-value<0.05 is significant.
† Kaplan-Meier Survival analysis with Log-rank test.
†† Adjusted for Tumor Clinicopathology and Age.
††† Hazard Ratio for Reduced DFS.