Table 3.

Serum Bone Turnover Markers

Serum Markers of Bone Resorption	Levels dependent on eGFR (cleared renally)?
Serum amino-terminal cross- linking telopeptide of type 1 collagen (s-NTX)	Yes
Serum carboxy-terminal cross-linking telopeptide of type 1 collagen (s-CTX)	Yes
Carboxy-terminal cross linking telopeptide of type 1 collagen (s-ICTP or CTX-MMP)	Yes
Serum tartarate-resistant acid phosphatase (TRAP5b)	No
Serum Markers of Bone Formation
Serum osteocalcin	Yes
Serum alkaline phosphatase	No
Bone specific alkaline phosphatase	No
Procollagen type 1C propeptide (s-PICP)	Yes
Procollagen type 1N propeptide (s-PINP)	No