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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Gastroenterology. 2013 Jul 25;145(5):1088–1097.e8. doi: 10.1053/j.gastro.2013.07.027

Figure 3. Acinar cells lacking Numb have reduced viability during caerulein-induced ADM.

Figure 3

(A–B I, IV) Gross morphology, (A–B II, V) H&E and (A–B III, VI) immunostaining for CK19 (brown) counterstained with Alcian Blue (bright blue) p48Cre;KrasG12D and p48Cre;KrasG12D ;Numbf/f pancreata 7 days after PBS or caerulein treatment. Scale bars represent 100µm. (C) Pancreas mass:body weight ratio of PBS and caerulein treated mice at day 7. * P<0.05, N=3–5.