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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Gastroenterology. 2013 Jul 25;145(5):1088–1097.e8. doi: 10.1053/j.gastro.2013.07.027

Figure 4. KrasG12D expressing acinar cells lacking Numb undergo more rapid and extensive dedifferentiation.

Figure 4

(A–A’) H&E staining and (B–B’) immunostaining for YFP (green), Cpa1 (red) and CK19 (blue) at 2 days after caerulein in p48CreER;KrasG12D;YFP and p48CreER;KrasG12D;Numbf/f;YFP pancreata. (C) Lumen diameters of ductal structures at 2 days after caerulein treatment. (D) qPCR analysis of Notch target genes 2 days after caerulein treatment. N=3–4.