Table 2.

Demographic Characteristics, Scan-Day Assessments, and V_T/f_P Data in Euthymic Bipolar Disorder Subjects and Matched Control Subjects

	CNS (n = 5)			CS (n = 5)			BDNS (n = 5)			BDS (n = 5)
	Mean		SD	Mean		SD	Mean		SD	Mean		SD
Age (yrs)	33.6		10.6	36.2		12.3	35.0		13.3	37.6		13.9
Years Diagnosed		NA			NA		9.4		10.1	14		9.6
Months Euthymic		NA			NA		8.1		9.0	9.8		11
Cigarettes/Day		NA		18.0		6.7		NA		15.6		7.2
Years Smoking		NA		16.4		11.7		NA		13.0		13.2
Scan-Day Mood Assessments
BDI	2.0		4.5	6.5		6.7	5.6		2.7	7.8		6.0
CES-D	5.2		6.8	10		9.2	15		6.9	14.4		11.3
HAM-D		NA			NA		3.6		2.7	3.8		1.1
MADRS		NA			NA		2.4		2.1	4.2		4.1
STAI-S	28		7.8	35.6		14.4	36		7.5	43		7.2
Young		NA			NA		1.4		2.6	3.2		2.8
Scan-Day Smoking Assessments
Desire		NA		7.8		4.5		NA		6.5		5.7
Relief		NA		8.8		6.3		NA		7.3		4.7
Withdrawal		NA		7.4		8.4		NA		9.4		8.0
VT/fP
	CNS		CS		BDNS		BDS
ROI	Mean	SD	Mean	SD	Mean	SD	Mean	SD	% Diff.a	% Diff.b	% Diff.c	% Diff.d
Frontal	39	2.8	54.9	11.3	50.6	17.9	49.1	9.8	4.8	3.2	−10.6	29.7
Anterior Cingulate	47	7.3	63	14	50.4	14.2	56.5	10.6	−3.2	−11	−11	8.0
Temporal	52	7.5	65.6	13.6	55.4	16.7	59.6	12.6	−2.6	−7.1	−9.1	6.1
Parietal	44	5.3	63.8	12.4	53.6	17.7	57.9	13.4	2.5	−7.4	−9.3	21.5
Hippocampus	56.6	19.3	71.4	17.8	67.2	32.8	75.8	13.2	−2.3	4.2	−8.6	3.3
Amygdala	54.9	14.7	68	16	53	22	60.7	17.9	−2.9	−6.8	−8.8	6.5
Striatum	61	9.4	76	19	64.6	18.4	69.3	15.3	12	−11	6.1	19
Thalamus	114	18.5	123	36.9	117	40.4	112	16.2	−11	−14	−10	−4.3

% Diff., percent difference; BDI, Beck Depression Inventory; BDS, smokers with bipolar disorder, BDNS, nonsmokers with bipolar disorder; CES-D, Center for Epidemiologic Studies Depression scale; CS, control smokers, CNS, control nonsmokers; HAM-D, Hamilton Rating Scale for Depression; NA, not applicable; MADRS, Montgomery-Åsberg Depression Rating Scale; STAI-S, State–Trait Anxiety Inventory State subscale; Young, Young Mania Scale; V_T/f_P, receptor availability.

^aAll bipolar disorder vs. all control subjects.

^bBDNS vs. BDS.

^cBDS vs. CS.

^dBDNS vs. CNS.