Table 3. Association of Highest quartile of FGF23 with nonspine fractures stratified beGFRCrCysC.
| HR (95%CI) | HR (95%CI) | |
|---|---|---|
|
|
||
| FGF23 Quartile 4 vs. Q3,2,1 | eGFR <60 | eGFR≥60 |
| Number of fractures/total N | 73/313 | 304/1345 |
| Unadjusted | 1.88 (1.12-3.14) | 0.93 (0.69-1.26) |
| Age adjusted | 2.06 (1.21-3.51) | 0.96 (0.71-1.3) |
| Base Model | 2.25 (1.26-4) | 0.94 (0.69-1.27) |
| MV | 2.02 (1.07-3.79) | 0.91 (0.66-1.25) |
Quartile cut-points 12.2, 16.6, 22.4 pg/ml
Base Model adjusted for age, race, BMI and clinic site
MV model adjusted for base model and vitamin D, PTH, walking speed, alcohol use, hip BMD, fracture history and serum phosphorus