Fig. 1.

Chromatin landscape of the survival of motor neuron 2 (SMN2) gene in treated and untreated fibroblast cells. Read distribution for all analyzed datasets was calculated across the whole gene body plus 1 kilo base-pair (bp) up- and downstream using SeqMonk. Read counts were summed into 100 bp bins before plotting. Regions determined by Model-based Analysis for ChIP-Seq (MACS) to be significantly enriched in unexposed (Mock) cells or significantly differentially enriched after exposure were indicated in the bottom panel. Modifications not displaying significant enrichment were omitted to aid readability. Putative CpG islands (CGI) around the SMN2 transcription start site as determined by Hauke et al. [117] are indicated in green. VPA valproic acid, SAHA suberoylanilide hydroxamic acid