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Histone post-translational modifications and variants. a Schematic drawing of a nucleosome with the 4 canonical histones (H2A, H2B, H3, and H4), the linker histone H1 and their variants. b Currently known covalent histone post-translational modifications PTMs are highlighted on the N- and C-terminal tails of each histone. Me = methylation; Ac = acetylation; Ub = ubiquitination; Ph = phosphorylation
