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. 2013 Sep 23;9(9):966–979. doi: 10.7150/ijbs.6996

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 4 — The effect of IL-8 on occludin, claudin-5 and ZO-1 mRNA expression. IL-8 induced tight junction permeability in endothelium with decreased mRNA level of occludin, claudin-5 and ZO-1 in a dose- and time-dependence manner. (A) Representative bands of tight junction mRNA expression. (B), (C) and (D) The level of β-actin in each group was used as intrinsic controls, and relative expression mRNA of occludin, claudin-5 and ZO-1 were calculated, respectively. Values represented the mean±S.D. (n=3). *, P<0.05 denoted statistically significant difference compares to control.

Fig 4 — The effect of IL-8 on occludin, claudin-5 and ZO-1 mRNA expression. IL-8 induced tight junction permeability in endothelium with decreased mRNA level of occludin, claudin-5 and ZO-1 in a dose- and time-dependence manner. (A) Representative bands of tight junction mRNA expression. (B), (C) and (D) The level of β-actin in each group was used as intrinsic controls, and relative expression mRNA of occludin, claudin-5 and ZO-1 were calculated, respectively. Values represented the mean±S.D. (n=3). *, P<0.05 denoted statistically significant difference compares to control.