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. 2013 Sep 27;10(12):1702–1714. doi: 10.7150/ijms.7114

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 2 — Air space enlargement was quantitatively analyzed. (A) Mean linear intercept was significantly decreased in comparison to the group administered a nonsilencing oligoneucleotide (CON) at days 2 and 4 after VEGF siRNAs #2 and #3 administration. There was a tendency towards recovery at day 7. Mean linear intercept at day 4 was significantly recovered in the groups which were administered recombinant VEGF or DCI on day 2, in comparison to the siRNAs only groups, close to the control level. n=4 in each group at each time point. *p<0.05 vs CON, ** p<0.05 between the indicated groups. (B) Number of alveoli per field was significantly decreased in comparison to the group administered a nonsilencing oligoneucleotide (CON) at days 2 and 4 after VEGF siRNAs #2 and #3 administration. There was a tendency towards recovery at day 7. Number of alveoli per field at day 4 was significantly recovered in the groups which were administered recombinant VEGF or DCI on day 2, in comparison to the siRNAs only groups, close to the control level. n=4 in each group at each time point. *p<0.05 vs CON, ** p<0.05 between the indicated groups. (C) Lung volume index (LVI) was significantly increased in comparison to the group administered a nonsilencing oligoneucleotide (CON) at days 2 and 4 after VEGF siRNAs #2 and #3 administration. There was a tendency towards recovery at day 7. LVI at day 4 was significantly recovered in the groups which were administered recombinant VEGF or DCI on day 2, in comparison to the siRNAs only groups, close to the control level. n=4 in each group at each time point. *p<0.05 vs CON, ** p<0.05 between the indicated groups.