Fig 3.

(A, B) Prevalence and (C, D, E) incidence of (A, C) GI and (B, D, E) genitourinary (GU) adverse effects. (A, B) Prevalence plots display baseline, acute (3 months), and late reactions (≥ 6 months). (C, D, E) Cumulative incidence plots display first grade ≥ 2 toxicity occurring ≥ 3 months after completing irradiation using (C, D) original GI and GU definitions and (E) amended GU criteria. P values compare adverse reactions by treatment arm using Gray's test. Vertical bars depict 95% CIs. CIMRT, conventional fractionated intensity-modulated radiotherapy; HIMRT, hypofractionated intensity-modulated radiotherapy.