Table 2.

Niacin Action on Cytokine Production by Macrophages from Mice Injected with LPS

Treatment	Cytokines levels (pg/ml)
	IL-1β	TNF-α	IL-6
PBS	Non detectable	23 ± 14	35± 18
LPS	458 ± 57*	856 ± 101*	934 ± 123*
PBS + Niacin	Non detectable	19 ± 16	32 ± 25
LPS + Niacin	209 ± 32* #	486 ± 52* #	492 ± 67* #

Control mice were injected with PBS or LPS (20 mg/Kg) and were simultaneously orally treated with or without Niacin (250 mg/Kg). After 12 h, macrophages were collected and incubated for other 12 h in supplemented medium. Cell free supernatants were obtained to determine cytokine levels as described in Fig. (4). Data are mean ± S.E.M. of three animals *p<0.05 respect the corresponding PBS injected mice, #p<0.05 respect the corresponding non Niacin treated mice