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. Author manuscript; available in PMC: 2013 Oct 23.
Published in final edited form as: J Am Chem Soc. 2012 Jul 26;134(32):13164–13167. doi: 10.1021/ja304115q

Figure 4.

Figure 4

Specific binding of chimeric DNA molecule engineered-Fe-Fe3O4 CSNPs to target cancer cells. a) Schematic illustration of the binding event, b) Flow cytometry histograms of CEM (target) and Ramos (control) cells incubated with buffer only, aptamer (200 nM) and engineered Fe-Fe3O4 CSNPs (5 nM). PI-CEM and PI-Ramos are CEM and Ramos cells pre-incubated with 1.5 μM unlabeled aptamer. c) T2-weighted MRI image of engineered Fe-Fe3O4 CSNPs only (top), CEM (middle) and Ramos (bottom) cells treated with engineered Fe-Fe3O4 CSNPs. Lipid-PEG-Sgc8 was used as the chimeric DNA molecule here.