Skip to main content
. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: J Am Chem Soc. 2013 May 3;135(19):7223–7234. doi: 10.1021/ja3125417

Table 4.

Concentration of 5a and 5b in Plasma and Tumor Tissue in SCID Mice Bearing SJSA-1 Tumors when Dosed with Either 5a or 5b.

Dosing Plasma Concentration (ng/ml)a
Isomer 1 h 6 h 24 h
5b 5b 16800±1931 2577±815 5.9±0.8
5a 3343±1385 47±20 BLQb
5a 5b 2380±448 210±141 BLQ
5a 617±97 75±24 BLQ
Tumor Concentration(ng/g)a
1 h 6 h 24 h
5b 5b 19133±3775 1963±683 BLQ
5a 1122±297 65±24 BLQ
5a 5b 1797±527 120±84 BLQ
5a 2973±1036 27±18 BLQ
a

Three mice per time point.

b

BLQ: below the lower limit of quantification.