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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: Sci Transl Med. 2013 Sep 4;5(201):201ra119. doi: 10.1126/scitranslmed.3005954

Figure 3. SRS and H&E images of frozen human GBM xenografts.

Figure 3

Images are representative of 6 mice. Images were taken with SRS microscopy, and then stained with H&E for comparison. Lipids have been assigned to the green channel and proteins to the blue channel. (A) A thin (10 µm), full section of snap-frozen brain from implanted human GBM xenograft in mice. (B) High-magnification view of normal to minimally hypercellular cortex. (C) Infiltrating glioma with normal white matter bundles (asterisk), tumor-infiltrated bundles (arrow), and dense tumor cells (arrowhead). (D) High-density glioma. FOVs similar to these were used to populate the Web-based survey to quantitatively compare SRS and H&E microscopy.