Table 1. Quantitative comparison of H&E histology and SRS microscopy.
Three neuropathologists (R1, R2, and R3) reviewed a series of 75 H&E-stained tissues and 75 corresponding SRS images and recorded their diagnoses via Web-based survey. The category indicated as “normal” in the table represents FOVs categorized as normal to minimally hypercellular tissue with scattered atypical cells.
| Diagnosis | R1 | R2 | R3 | Overall accuracy (%) |
||||
|---|---|---|---|---|---|---|---|---|
| Correct | Incorrect | Correct | Incorrect | Correct | Incorrect | |||
| Normal | H&E | 25 | 0 | 25 | 0 | 25 | 0 | 100 |
| SRS | 24 | 1 | 25 | 0 | 25 | 0 | 98.7 | |
| Infiltrating glioma |
H&E | 25 | 0 | 25 | 0 | 25 | 0 | 100 |
| SRS | 25 | 0 | 24 | 1 | 25 | 0 | 98.7 | |
| High-density glioma |
H&E | 25 | 0 | 25 | 0 | 25 | 0 | 100 |
| SRS | 25 | 0 | 25 | 0 | 25 | 0 | 100 | |
| TOTAL | 149 | 1 | 149 | 1 | 150 | 0 | 99.5 | |