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. Author manuscript; available in PMC: 2013 Oct 23.

Published in final edited form as: Gastroenterology. 2009 Dec 21;138(3):1166–1177. doi: 10.1053/j.gastro.2009.12.005

PDG undergo hyperplasia in response to chronic injury. Overviews of the proximal ductal systems of a control animal (A) and an animal with chronic injury and metaplasia (B). (A) The normal pancreas has few, small PDG (arrows) with a regular, single-layer lining of mucinous appearance (insets) in a thin ductal mesenchyme. (B) In chronic injury PDG significantly increase in both number and size (arrows). PDG exhibit hyperplasia, a complex morphology (asterisk) and are lined by a less regular epithelium with several layers and papillations (insets). Changes are more pronounced in proximal PDG. The ductal mesenchyme is thickened.

PDG undergo hyperplasia in response to chronic injury. Overviews of the proximal ductal systems of a control animal (A) and an animal with chronic injury and metaplasia (B). (A) The normal pancreas has few, small PDG (arrows) with a regular, single-layer lining of mucinous appearance (insets) in a thin ductal mesenchyme. (B) In chronic injury PDG significantly increase in both number and size (arrows). PDG exhibit hyperplasia, a complex morphology (asterisk) and are lined by a less regular epithelium with several layers and papillations (insets). Changes are more pronounced in proximal PDG. The ductal mesenchyme is thickened.