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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Cytokine. 2013 Aug 26;64(2):10.1016/j.cyto.2013.08.001. doi: 10.1016/j.cyto.2013.08.001

Fig. 3. Thymocyte development in IL-6 transgenic mice.

Fig. 3

(A) Transgenic IL-6 expression in IgHKOIL6Tg mice. Serum levels of transgenic human IL-6 were determined by ELISA. Results show the mean +/− SEM of two independent experiments with total six IgHKO and seven IgHKOIL6Tg mice.

(B) Thymocyte development in IgHKOIL6Tg mice. Contour plots show CD4/CD8 profiles of total thymocytes (top) and of TCRβ+HSAlo mature thymocytes (bottom).

(C) Thymocyte numbers in IgHKOIL6Tg mice. Total thymocyte numbers were determined in five separate experiments from seven IgHKO and nine IgHKOIL6Tg mice.

(D) CD4/CD8 lineage differentiation in IgHKOIL6Tg mice. CD4/CD8 ratio was determined from TCRβ+HSAlo mature thymocytes. Data show mean +/− SEM of four independent experiments with a total of seven IgHKO and six IgHKOIL6Tg mice.