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. Author manuscript; available in PMC: 2014 May 3.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 Apr 3;52(19):5046–5051. doi: 10.1002/anie.201301018

Scheme 6.

Scheme 6

Cu-catalyzed γ- and diastereoselective coupling of allenes with carbonyls can be performed enantioselectively through the use of chiral bis-phosphine ligands; >98% conv. in all cases. For exact conditions, see Table 1 and Scheme 5.