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. Author manuscript; available in PMC: 2014 Jun 21.
Published in final edited form as: Life Sci. 2013 May 5;92(23):1145–1150. doi: 10.1016/j.lfs.2013.04.014

Fig. 1.

Fig. 1

Inhibition of sEH by orally administered inhibitor delays lethality of prion infection. A) Mice inoculated by intracerebroventricular (i.c.) route and administered vehicle (PEG400, 1% in drinking water) displayed median survival time of 163 days which was not significantly different than the group receiving 1 mg/kg/day t-AUCB which had a median survival time of 165 days (log-rank test p = 0.86). B) Mice inoculated by intraperitoneal (i.p.) route and administered vehicle (PEG400, 1% in drinking water) displayed a delayed median survival time of 207 days compared to i.c. inoculation. This survival time was further delayed in the t-AUCB (1 mg/kg/day in drinking water) treatment groups which had a median survival time of 216 days (log-rank test p = 0.025).