Table 1.

Treatment groups, histological and immunohistochemical assessment of pathology and prion presence.

Group	Infection	Treatment	n	Median survival time (days)	Histologya (brain)	Immunohistochemistryb (brain PrPsc/spleen)
1	None	Vehiclec	15	N/A	Negative	Negative
2	i.c. scrapied	Vehiclec	15	163	Positive	Positive
3	i.c. scrapied	t-AUCB	15	165	Positive	Positive
4	i.c. healthye	t-AUCB	8	N/A	Negative	Negative
5	i.p. scrapied	Vehiclec	15	207	Positive	Positive
6	i.p. scrapied	t-AUCB	14f	216	Positive	Positive
7	i.p. healthye	t-AUCB	8	N/A	Negative	Negative

N/A, not applicable.

^aSemi quantitative lesion scores from brainstem, cerebellum, diencephalon, telencephalon and cortex.

^bPrP^sc deposition.

^cPEG400, 1% in drinking water.

^dInfected brain homogenate.

^eHealthy brain homogenate.

^fOne mouse out of 15 mice in this group did not display behavioral signs of infection and was negative for the presence of PrP^sc in the brain.