Table 3.
Cardiac healing? green indicates regeneration, red indicates fibrotic wound
| Injury | Assay | References |
|---|---|---|
| Cryoinjury of the right ventricle | Increased healing vs. C57BL/6; | (Leferovich et al., 2001) |
| 60 days post injury | ||
| >Reduced hydroxyproline | ||
| >Increased mitosis | ||
| >Increased function by echo | ||
| Cryoinjury of the right ventricle | Increased healing vs. C57BL/6; | (Bedelbaeva et al., 2004) |
| > MT | ||
| > less collagen | ||
| Permanent occlusion | No control strain | (Oh et al., 2004) |
| 27 and 104 days post-surgery | ||
| >MRI demonstrated transmural infarction with fibrosis | ||
| > MT demonstrated fibrosis | ||
| Transient 45′ IR | No difference vs. C57BL/6; | (Abdullah et al., 2005) |
| 24 hours and 10 weeks post injury | ||
| >Calculated infarct area with TTC and MT staining | ||
| Cryoinjury, superficial | Increased healing vs. C57BL/6; | (Naseem et al., 2007) |
| Restoration of cardiac function in MRL hearts | ||
| Less collagen deposition | ||
| Cryoinjury, severe | Increased survival | |
| Reduced scarring | ||
| Decreased apoptosis | ||
| Decreased ventricular remodeling | ||
| Not complete regeneration | ||
| Transmural myocardial injury, severe | Increased survival | |
| Increased cellular proliferation | ||
| Reduced scarring | ||
| Decreased ventricular remodeling | ||
| Not complete regeneration | ||
| Permanent occlusion | No difference vs. C57BL/6; | (Robey and Murry, 2008) |
| 1 – 90 days post injury | ||
| >Calculated infarct area with H&E and Sirius red staining | ||
| >Mitosis | ||
| Cryoinjury | No difference vs. C57BL/6; | |
| 7 and 28 days post injury | ||
| >H&E and Sirius red staining | ||
| >Mitosis | ||
| Permanent occlusion | No difference vs. C57BL/6; | (Grisel et al., 2008) |
| 60 days post injury | ||
| >Calculated infarct area with H&E and Sirius red staining | ||
| >Mitosis | ||
| Cryoinjury | No difference vs. C57BL/6; | |
| 60 days post injury | ||
| >H&E and Sirius red staining | ||
| >Mitosis | ||
| Permanent occlusion | No difference vs. C57BL/6; | (Cimini et al., 2008) |
| 0, 5, 15, 60 days post injury | ||
| >Heart function by echo and Millar catheter | ||
| > MT, H&E | ||
| > Mitosis | ||
| Permanent occlusion | No difference vs. C57BL/6; | (Moseley et al., 2011) |
| 4 weeks post injury | ||
| >Calculated infarct area with MT staining | ||
| >Heart function; contractility, pressure and volume | ||
| Muscular dystrophy | Reduced fibrosis and reduced functional decline vs. DBA/2J; | Heydemann manuscript in preparation |
| >Hydroxyproline | ||
| >Echocardiography |
TTC-(2,3,5)-triphenyltetrazolium: MT- Masson’s trichrome; H&E- hematoxylin and eosin staining; IR- ischemia reperfusion injury