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. 2013 Oct 18;62(11):3751–3759. doi: 10.2337/db13-0645

FIG. 7.

FIG. 7.

PPARγ expression is reduced in high glucose–treated islets and adult db/db mouse islets, which is reversed by rosiglitazone. A: Isolated islets from lean mice were treated with 5.6 or 28 mmol/L glucose, 20 μmol/L rosiglitazone (Rosi), with or without 20 μmol/L GW9662 (GW), for 72 h. *P < 0.05 vs. 28 mmol/L group; #P < 0.05 vs. 28 mmol/L + Rosi group (n = 6). B: Isolated islets from 12-week-old m+/db and db/db mice were treated with 20 μmol/L Rosi with or without 20 μmol/L GW for 72 h. *P < 0.05; **P < 0.01 vs. db/db group (n = 6). C: Islet PPARγ expression was examined in m+/db and db/db mice at 4, 8, and 12 weeks of age. ***P < 0.001 vs. age-matched m+/db group; ###P < 0.001 vs. 4-week db/db group (n = 4). β-Actin was used as a loading control. Densitometry is shown and calculated as PPARγ/β-actin. Data are means ± SEs.