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Serum and WAT cytokines and chemokines in PfnWT and PfnHet. A and B: Serum levels of candidate cytokines/chemokines were assayed by multiplex ELISA in fasted PfnWT and PfnHet fed NC or HFD for 12 weeks (n = 5–8/group). *P < 0.001; **P < 0.0001. C and D: qRT-PCR for chemokines and ATM signatures in sorted ATMs and whole epidydmal WAT from PfnWT and PfnHet fed HFD for 12 weeks (n = 9–12/group for ATM, n = 7–9/group for whole WAT). *P < 0.05; **P < 0.001; ***P < 0.0001.
