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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Medchemcomm. 2013 Jul 15;4(9):10.1039/C3MD00134B. doi: 10.1039/C3MD00134B

Table 4.

Antiproliferative activities of 4 and 7 in MDA-MB-231 and MDA-MB-468 cells.a

compd GI50 (μM) compd GI50 (μM)
MDA-MB-231 MDA-MB-468 MDA-MB-231 MDA-MB-468
4a 32.62 ± 13.97 56.46 ± 17.97 7a 27.17 ± 11.40 53.54 ± 29.54
4b 18.66 ± 2.24 20.28 ± 7.40 7b 21.43 ± 9.86 24.41 ± 3.33
4c 26.86 ± 12.90 26.27 ± 4.83 7c 25.52 ± 9.93 27.37 ± 4.52
4d >100 >100 7d 39.66 ± 22.46 29.80 ± 8.41
4e 15.64 ± 7.66 11.11 ± 1.73 7e 2.43 ± 0.13 2.24 ± 0.40
4f 8.46 ± 2.56 8.91 ± 1.28 7f 1.60 ± 0.51 0.44 ± 0.14
4a′ >100 >100 1 4.13 ± 0.54 3.34 ± 0.93
Dox 0.15 ± 0.57 0.085 ± 0.029
a

The GI50 values, which represent the concentrations needed to inhibit the growth of the cancer cells by 50% during a 72 h incubation period, are presented as mean ± SD of at least two independent experiments performed in duplicates. If the GI50 did not reach at the highest concentration tested at 100 μM, it is designated as >100.