Table 1.
General characteristics of the study populations
| Variable |
Costa Rica Study
|
Nurses’ Health Study
|
Health Professionals Follow-Up Study
|
|||
|---|---|---|---|---|---|---|
| Cases (n = 1650) | Controls (n = 1650) | Cases (n = 403) | Controls (n = 797) | Cases (n = 435) | Controls (n = 860) | |
| Age, years | 58.4 ± 10.9 | 58.1 ± 11.1 | 60.2 ± 6.3 | 59.6 ± 6.5 | 64.5 ± 8.6 | 64.2 ± 8.6 |
| % Female | 26 | 26 | 100 | 100 | 0 | 0 |
| % History of hypertension | 39 | 30 | 50 | 27 | 37 | 29 |
| % History of hypercholesterolemia | 31 | 27 | 53 | 41 | 49 | 40 |
| % History of diabetes | 24 | 14 | 15 | 6 | 9 | 4 |
| % Current smokers | 39 | 22 | 27 | 25 | 10 | 9 |
| Body mass index, kg/m2 | 25.9 ± 3.9 | 26.3 ± 4.3 | 26.6 ± 5.4 | 25.1 ± 4.3 | 26.0 ± 3.2 | 25.6 ± 3.3 |
| Adipose tissue fatty acids, % total | ||||||
| Alpha-linolenic | 0.62 ± 0.21 | 0.65 ± 0.21 | – | – | – | – |
| Linoleic | 15.1 ± 3.8 | 15.6 ± 3.8 | – | – | – | – |
| Minor allele frequency, % | ||||||
| rs10498676 (A/G) | 24 | 24 | 18 | 19 | 21 | 20 |
| rs3734397 (A/G) | 18 | 19 | 24 | 23 | 22 | 24 |
| rs17239120 (C/G) | 10 | 10 | 6 | 7 | 6 | 6 |
| rs17544464 (C/T) | 21 | 18 | 7 | 6 | 6 | 6 |
| rs2115564 (A/C) | 48 | 50 | 47 | 46 | 46 | 47 |
| rs2294867 (A/C) | 44 | 43 | 38 | 36 | 37 | 37 |
| rs761179 (C/T) | 25 | 26 | 37 | 34 | 36 | 34 |