Table 4.
The risk of nonfatal myocardial infarction by ELOVL polymorphism
SNP | OR (95% CI) a | P-valueb |
---|---|---|
rs10498676 (ELOVL2) | ||
Costa Rica Study (n = 3300) | 1.01 (0.90, 1.13) | 0.88 |
NHS (n = 1200) | 0.96 (0.76, 1.20) | 0.70 |
HPFS (n = 1295) | 1.12 (0.92, 1.36) | 0.28 |
rs3734397 (ELOVL2) | ||
Costa Rica Study (n = 3300) | 0.98 (0.87, 1.11) | 0.77 |
NHS (n = 1200) | 1.09 (0.88, 1.34) | 0.43 |
HPFS (n = 1295) | 0.92 (0.76, 1.11) | 0.39 |
rs17239120 (ELOVL4) | ||
Costa Rica Study (n = 3300) | 0.95 (0.81, 1.11) | 0.51 |
NHS (n = 1200) | 0.94 (0.66, 1.34) | 0.74 |
HPFS (n = 1295) | 0.94 (0.66, 1.32) | 0.71 |
rs17544464 (ELOVL5) | ||
Costa Rica Study (n = 3300) | 0.87 (0.77, 0.98) | 0.02 |
NHS (n = 1200) | 1.35 (0.94, 1.93) | 0.10 |
HPFS (n = 1295) | 0.91 (0.63, 1.30) | 0.59 |
rs2115564 (ELOVL5) | ||
Costa Rica Study (n = 3300) | 0.91 (0.83, 1.01) | 0.07 |
NHS (n = 1200) | 0.97 (0.82, 1.16) | 0.77 |
HPFS (n = 1295) | 0.97 (0.82, 1.14) | 0.70 |
rs2294867 (ELOVL5) | ||
Costa Rica Study (n = 3300) | 0.94 (0.85, 1.03) | 0.20 |
NHS (n = 1200) | 1.03 (0.86, 1.24) | 0.76 |
HPFS (n = 1295) | 1.05 (0.89, 1.25) | 0.56 |
rs761179 (ELOVL5) | ||
Costa Rica Study (n = 3300) | 1.06 (0.94, 1.18) | 0.35 |
NHS (n = 1200) | 0.96 (0.80, 1.15) | 0.66 |
HPFS (n = 1295) | 1.07 (0.90, 1.27) | 0.45 |
Abbreviations: CI, confidence interval; HPFS, Health Professionals Follow-Up Study; NHS, Nurses’ Health Study; OR, odds ratio.
All odds ratios were estimated using additive models. Models fit to the Costa Rican data were adjusted for age/sex/residence (by matching) and ancestry. Models fit to the NHS and the HPFS data were adjusted for sex (by restriction) and age.
Unadjusted for multiple comparisons.