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. Author manuscript; available in PMC: 2013 Oct 23.
Published in final edited form as: J Mol Cell Cardiol. 2012 May 14;53(2):206–216. doi: 10.1016/j.yjmcc.2012.05.003

Figure 7. Phenylephrine-induced hypertrophy is partially abolished by cholinesterase inhibition in neonatal cardiac myocytes.

Figure 7

A. Sample images of α-actinin/DAPI stained neonatal rat cardiomyocytes treated for 48 hours with phenylephrine (PHE) or PHE/PYR. Scale bar=10 μm. B. Bar graph showing partial inhibition of PHE induced hypertrophy in PYR-treated neonatal cardiomyocytes. n=number of cells analysed. C. PYR treatment of PHE exposed cardiomyocytes significantly prevents ANP mRNA upregulation. Addition of either atropine or L-NAME blunted PYR effects on ANP mRNA in PHE-exposed cells. n=3-7 samples from each group. *p<0.05 when compared to control and PHE/PYR group. # p<0.05 when compared to control group .