Table 2. MMR suppression of homeologous recombination during S and G2/M.
Inverted repeat recombination rate (His+) (fold increase)* | |||||
---|---|---|---|---|---|
100% homologous substrate | 91% homeologous substrate | ||||
| |||||
Relevant genotype | Strain RDKY |
Rate | Strain RDKY |
Rate | Ratio 91/100† |
| |||||
msh3 Δ | 7672 | 3.9 [3.0-5.2] × 10−6 (1) | 7673 | 2.6 [1.9-3.0] × 10−7 (1) | 0.07 |
msh3Δ msh6Δ | 7674 | 3.6 [3.3-4.8] × 10−6 (0.9) | 7675 | 1.4 [1.3-1.6] × 10−6 (5.4) | 0.39 |
G2/M-MSH6 msh3 Δ | 7676 | 5.8 [4.4-9.1] × 10−6 (1.5) | 7677 | 7.8 [5.0-10.2] × 10−7 (3) | 0.13 |
S-MSH6 msh3 Δ | 7678 | 4.7 [3.8-6.2] × 10−6 (1.2) | 7679 | 7.9 [6.3-11.8] × 10−7 (3) | 0.17 |
Inverted repeat recombination rate (His+) with 95% C.I. in square brackets. The number in parentheses represents the fold increase relative to the msh3Δ strain rate for each respective recombination substrate.
The inverted repeat recombination rate for the 91% homeologous substrate divided by the inverted repeat recombination rate for the 100% homologous substrate.